Menzies Lunchtime Seminar - The airway microbiota in health and disease


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Presenter:  Associate Professor Mike Taylor, School of Biological Sciences, University of Auckland

Date: Mar 08, 2018

Time: 12:00pm to 1:00pm

Contact person:  Robyn Marsh
T: (08) 8946 8563
E: robyn.marsh@menzies.edu.au

Location:  Auditorium, John Mathews Building (Bldg 58), Royal Darwin Hospital Campus (available on WebEx)

Target audience:  The Menzies seminars are free of charge and open to the general public. No need to RSVP if attending in person

Abstract: The airway microbiota is an under-explored microbial community relevant to both health and disease.  While a microbial role is likely in many airway diseases, the exact nature of the host-microbe interaction often remains unclear.  I will present two lines of recent research from my lab: (1) the microbiome in adults with chronic sinus disease, and (2) the paediatric lung microbiota in non-cystic fibrosis bronchiectasis.  Chronic rhinosinusitis (CRS) is a common, debilitating condition characterised by long-term inflammation of the nasal cavity and paranasal sinuses.  It affects ~5% of adults and annual treatment costs associated with CRS exceed US$8.6 billion in the USA alone.  Our data suggest that, rather than a simple one pathogen, one disease model, CRS may be associated with a breakdown, or dysbiosis, of the entire microbial community.  Such a shift in microbiota composition may in turn drive an exacerbated and ongoing inflammatory response.  By contrast, the diversity of the lung microbiota in children with non-CF bronchiectasis appears to be largely retained, at least at the point of disease diagnosis.  I will present results derived from 16S rRNA gene amplicon sequencing, immunological assays and ecological network analyses, and will discuss potential clinical implications of our findings

Biography: Mike completed his PhD at UNSW in 2004 before undertaking post-doctoral research at the University of Vienna.  He began his faculty position in Auckland in 2007, with his research exploring interactions between animal (including human) “hosts” and associated microbial communities.  Mike’s human microbiome research centres on the airway microbiota and roles of the gut microbiome in type 2 diabetes and autism.  He has >80 publications and was a Thomson Reuters Highly Cited Researcher in 2015.  Mike is Vice-President of the NZ Microbiological Society, Co-Convenor of the NZ Microbial Ecology Consortium, and Board Member of the International Society for Microbial Ecology.

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Auditorium | John Mathews Building (Bldg 58), Royal Darwin Hospital Campus - view map (available on WebEx)

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Menzies Lunchtime Seminar - Associate Professor Mike Taylor
Thursday, March 8, 2018
12:00 pm  |  Australia Central Time (Darwin, GMT+09:30)  |  1 hr
Meeting number (access code): 570 509 335
Meeting password: APpyYBbT

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