Menzies Weekly Seminar - Complementing antibodies to prevent malaria: the importance of antibody function in protective immunity


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Presenter:  Dr Michelle Boyle

Date: Apr 10, 2018

Time: 11:00am to 11:30am

Contact person:  Menzies Communications Team
T: 08 8946 8658
E: communications@menzies.edu.au

Location:  Auditorium | John Mathews Building (Bldg 58), Royal Darwin Hospital Campus - available on WebEx

Abstract: The key feature of antibodies in protection from malaria has been established since the 1960s. However, the specific mechanisms of antibody function that block parasite growth and prevent disease remain elusive. This key knowledge gap has hampered malaria vaccine development. Here we describe the central role of complement proteins (soluble mediators of sera) in antibody function that prevent parasite growth. We show that the majority of antibodies that bind malaria parasites only function in the presence of complement. Children with high levels of complement interacting antibodies were protected from clinical disease in longitudinal studies. Both IgG and IgM are able to interact with complement factors to block parasite growth. Our findings directly inform malaria vaccine development by identifying the specific function of antibodies required for protective immunity.

Biography: Michelle is an Honorary Fellow at Menzies and research officer at the Burnet Institute. Read more on her profile page.

Next: Tuesday, 17 April
Associate Professor Gurmeet Singh -
“The Aboriginal Birth Cohort study- 30 years on”

  • The presentations will be 20 minutes with 10 minutes for questions.
  • Please feel free to forward this notice to your colleagues and associates

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Every Tuesday, from Tuesday, February 13, 2018, to Tuesday, December 11, 2018
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