Menzies Weekly Seminar - “A decade on: Clinical characteristics of Indigenous children with CSLD/bronchiectasis”

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Presenter:  Dr Gabrielle McCallum

Date: Jul 02, 2019

Time: 12:00pm to 12:30pm

Contact person:  Menzies Communications Team
T: 8946 8658

Location:  Auditorium | John Mathews Building (Bldg 58), Royal Darwin Hospital Campus (also available on WebEx)

Prospective, longitudinal studies of children with bronchiectasis are lacking in the current era. We aimed to evaluate the clinical and lung function outcomes and their associated risk factors in Indigenous children and adolescents from Australia, Alaska and New Zealand who participated in our previous chronic suppurative lung disease (CSLD)/bronchiectasis studies (during 2004-10).

Between 2015 and 2018, we evaluated 131/180 (73%) children and adolescents at a single follow-up visit. Standardised questionnaires, clinical examination and spirometry and reviewed medical records and chest computed tomography scans were undertaken.

Participants were seen at a median age of 12.2-years (interquartile range [IQR] 10.4-14.3), which was a median 9-years ([IQR] 8-10) after their original recruitment. With increasing age, rates of acute lower respiratory infections (ALRI) declined while lung function was within population norms with median forced expiry volume in one-second %predicted of 90% (IQR, 81-105) and median forced vital capacity (FVC) %predicted of 98% (IQR 85-114). However, 39% continued to experience chronic cough episodes. Their overall global rating judged by symptoms and ALRI frequency was well (20%), stable (44%) or improved (36%). Household tobacco exposure was the sole explanatory variable associated with an adverse outcome, which was confined to a lower FVC %predicted (adjusted mean difference; -11.52 (95% confidence interval -21.5, -1.6, p=0.02) found on multivariate regression.

Respiratory outcomes of children with CSLD/bronchiectasis from a population at high-risk of early mortality at this stage are encouraging. Prospective studies to further inform management throughout the life course into adulthood are now needed.

Program evaluation applies the New World Kirkpatrick Model to assess the impact of training on adult learning. In addition, we are examining changes pre- and post-training in trainee’s own lifestyle behaviours in smoking, nutrition and physical activity.

Gabrielle is an NHMRC Early Career Researcher, Senior Research Officer and Program Leader of Menzies’ child health respiratory. Read More on our website.

Next Tuesday Seminar on July 9: Professor Peter d’Abbs - “Drinking and its costs in the NT: exploring and explaining the connections”

  • The Menzies seminars are free of charge and open to the general public
  • The presentations will be 20 minutes with 10 minutes for questions.
  • Information about the roster for presentations can be obtained from the communications team on 8946 8658 or
  • Please feel free to forward this notice to your colleagues and associates

Menzies Tuesday Seminar Series

Occurs every Tuesday effective Tuesday, June 25, 2019 until Tuesday, December 10, 2019 from 12:00 PM to 1:00 PM, (UTC+09:30) Darwin
12:00 pm |  Australia Central Time (Darwin, GMT+09:30)  |  1 hr
Meeting number (access code): 571 124 917
Meeting password: utwt8Kwh
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